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Arimidex (Anastrozole)

Arimidex (generic name is anastrozole) is a very new drug developed for the treatment of advanced breast cancer in women. Anastrozole is a Selective Androgen Receptor Modulator (SARM) because it is a compound that acts directly on the androgen receptor. It acts by blocking the enzyme aromatase, subsequently blocking the production of estrogen. Since many forms of breast cancer cells are stimulated by estrogen, it is hoped that by reducing amounts of estrogen in the body the progression of such a disease can be halted. A daily dose of one tablet (1mg) can produce estrogen suppression greater than 80% in treated patients.

For the steroid using male athlete, Arimidex shows a great potential. Up to this point, drugs like Nolvadex and Proviron have been our weapons against excess estrogen. These drugs, especially in combination, do prove quite effective. But Arimidex appears to do the job much more efficiently and with less hassle. A single tablet daily, seems to be all one needs for an exceptional effect (some even report excellent results with only 1/4 tablets taken every day or every other day). When used with strong, readily aromatizing androgens such as Dianabol or testosterone, gynecomastia and water retention can be effectively blocked. In combination with Propecia (Finasteride), we have a great advance. With one drug halting estrogen conversion and the other blocking 5-alpha reduction (testosterone), related side effects can be effectively minimized. Here the strong androgen testosterone could theoretically provide incredible muscular growth, while at the same time being as tolerable as nandrolone. Additionally the quality of the muscle should be greater, the athlete appearing harder and much more defined without holding excess water.

There are some concerns with using an aromatase inhibitor such as this during prolonged steroid treatment however. While it will effectively reduce estrogenic side effects, it will also block the beneficial properties estrogen from becoming apparent (namely its effects on cholesterol values). Studies have clearly shown that when an aromatase inhibitor is used in conjunction with a steroid such as testosterone, suppression of HDL (good) cholesterol becomes much more pronounced. Apparently estrogen plays a role in minimizing the negative impact of steroid use. Since the estrogen receptor antagonist Nolvadex is shown not to display an anti-estrogenic effect on cholesterol values, it is certainly the preferred form of estrogen maintenance for those concerned with cardiovascular health.

Aromasin (Exemestane)

Aromasin is a steroidal suicide aromatase inhibitor, it is called a Selective Androgen Receptor Modulator because it is a compound that acts directly on the androgen receptor. Exemestane works to lower estrogen production in the body by blocking the enzyme responsible for synthesizing these hormones. Aromasin is for the treatment of breast cancer, specifically in post-menopausal women whose cancer has progressed following therapy with a first line agent such as tamoxifen.

Aromasin may perhaps be the most effective aromatase inhibitor available to date. While Femara and Arimidex boast of estrogen suppression around the 78-80% in their packaging inserts, Aromasin reports it can lower estrogen as much as 85% on average. Feedback from bodybuilders tends to support the preference for Aromasin over other anti-estrogens, so this my very well be the case. Regardless of which one is the true “king” aromatase inhibitor, all of the newer pharmaceutical agents, Arimidex, Femara, and Aromasin, should be looked at as extremely effective for reducing estrogen synthesis in the body. A possible 10% difference in inhibition between the weakest and the strongest of the three is really not going to amount to all that much during your next cycle. If you are looking at one of these agents to prevent gynecomastia and help you lose fat and water on your next cycle, they are all going to do a good job for you. If you absolutely need the best agent, my money would be on this one.

It is important to point out that there are some disadvantages to using an aromatase inhibitor over mixed estrogen agonist/antagonists (anti-estrogen) like Nolvadex and Clomid, the most notable being unwanted (negative) alterations in serum cholesterol values. This is because estrogen is tied with HDL (good) cholesterol synthesis and LDL (bad) cholesterol metabolism, and aromatase inhibitors block estrogenic action. Clomid and Nolvadex, on the other hand, tend to exert a positive influence on cholesterol values, as they are both active estrogens in the liver. If you are trying to prevent estogenic side effects like gynecomastia, bloating and excess water retention in general, these agents are probably better choices (they do the same job and are safer on your cholesterol levels).

Aromasin is very potent and can be used at lower dosages than the recommended 25mg daily. In fact, studies have shown maximum estrogen suppression in some patients with as little as 2.5mg per day. That is not a recommendation to smash each tablet into 10 little pieces, but it does make the current armchair advice of taking 1/2 a tablet every day or two seem well justified.

Clomid (Clomiphene Citrate)

Clomid is the brand name for the drug clomiphene citrate, it is called a Selective Estrogen Receptor Modulator (SERM) because it is a compound that acts directly on the estrogen receptor. The drug is not an anabolic steroid but a prescription drug generally prescribed to woman as a fertility aid due to the fact that it shows ability to stimulate ovulation.Clomid is a chemically synthetic estrogen with both agonist/antagonist properties. In certain target tissues is can block the ability of estrogen to bind with its corresponding receptor. Its clinical use is therefore to oppose the negative feedback of estrogens on the hypothalamic-pituitary-ovarian axis, which enhances the release of luteinizing hormone (LH) and follicle stimulating hormone (FSH).

Clomid when taken for athlete purposes does not offer a tremendous benefit to women. However, in men the negative feedback on the hypothalamic-pituitar-testicular axis will cause an elevation in both FSH and (primarily) LH which will result in an increase in natural testosterone level production. This affect can be beneficial to the athlete at the end of a steroid cycle when endogenous testosterone levels are depressed. If endogenous testosterone levels are not restored quickly, a dramatic loss in size and strength is likely to occur. This is due to the fact that without testosterone (or other androgens), the catabolic hormone cortisol becomes the dominant force affecting muscle protein synthesis (quickly bringing about a catabolic metabolism). Often referred to as the post-steroid crash, it can quickly eat up much of your newly acquired muscle. Clomid can play a crucial role in preventing this crash in athletic performance. As for woman, the only real use for Clomid is the possible management of endogenous estrogen levels near contest time. This can increase fat loss and muscularity, particularly in female troubles areas such as this hips and thighs.

Male athletes generally find that a daily intake of 50 -150mg over a four to six week period will bring endogenous testosterone production back to an acceptable level. This raise in testosterone should occur slowly but evenly throughout the period of intake. Studies have shown that a dose of 150mg of Clomid will raise your testosterone levels by around 150%.

Clomid can also help with elevated levels of estrogen during a cycle. A high estrogen level puts an athlete in serious risk of developing gynecomastia, which is an obvious unwanted side effect. With the intake of Clomid, the athlete can reduce the risk of developing gynecomastia. The drug also can ward of excess water/fat retention with the minimized estrogen activity. Unfortunately this is not always the case however, and many find it necessary to addition another anti-estrogenic drug. The most common adjunct is Proviron, an oral DHT used to competitively lower aromatase activity and raise the androgen to estrogen ratio.

As for toxicity and side effects, Clomid is considered a very safe drug. Bodybuilders seldom report any problems, but listed possible side effects do include hot flashes, nausea, dizziness, headaches and temporarily blurred vision. Such side effects usually only appear in females however, as they feel the effects of estrogen manipulation much more readily than men.

Femara (Letrozole)

Letrozole is a non-steroidal third generation aromatase inhibitor. It is a Selective Androgen Receptor Modulator (SARM) because it is a compound that acts directly on the androgen receptor. It is used to treat postmenopausal women with estrogen receptor-positive or estrogen receptor-unknown (unsure if the cancer is responsive to estrogen) breast cancer. The structure and activity of this compound are very similar to that of Arimidex (Anastrozole). Femara is typically used as a second line of treatment, after an estrogen-receptor antagonist like tamoxifen has failed to elicit a desirable response (although at times it is used as a first line option as well).

Femara and Arimidex represent the newest achievements in a long line of drugs targeting aromatase inhibition. These are amongst the most potent estrogen-lowering drugs made to date, working far more effectively than the non-selective first generation aromatase inhibitors, like Teslac and Cytadren, to come before them. The dosage of each tablet of Femara 2.5 milligrams, which according to the product insert was sufficient to lower estrogen levels by 78% during clinical trials. The drug, however, appears to still be extremely affective in much lower dosages. The package insert for the product itself comments that during clinical studies doses of .1 and .5 milligram produced 75% and 78% estrogen inhibition, respectively. When it comes to a product like this, typically the reflects what seems to work for almost everyone who takes it. A large number of people may respond extremely well to lower doses, however, to make sure each patient is receiving the proper benefit of the drug a standard effective dosage unit is ascertained and used.

It is important to point out that there are some disadvantages to using an aromatase inhibitor over mixed estrogen agonist/antagonists (anti-estrogen) like Nolvadex and Clomid, the most notable being unwanted (negative) alterations in serum cholesterol values. This is because estrogen is tied with HDL (good) cholesterol synthesis and LDL (bad) cholesterol metabolism, and aromatase inhibitors block estrogenic action. Clomid and Nolvadex, on the other hand, tend to exert a positive influence on cholesterol values, as they are both active estrogens in the liver. If you are trying to prevent estogenic side effects like gynecomastia, bloating and excess water retention in general, these agents are probably better choices (they do the same job and are safer on your cholesterol levels). But if you want that really tight, dry, defined look that is often sought after when you are cutting, Nolvadex or Clomid are not quite going to cut it. In such cases, I think you will find Femara to serve you well.

Like Arimidex, each tablet can be broken up if you desire to stretch out the value of the drug. In fact, with studies showing maximum inhibition in some patients with doses as low as 1/2 milligram, each 2.5 milligram tablet can be broken up in to as many as 5 separate doses (perhaps even more). But the typical use amongst bodybuilders is to cut the tabs in half, and take one every other day (unless needed daily). In terms of overall power, Femara seems to be a little bit more potent than Arimidex, at least by most people’s estimations. If both agents are available for the same price, Femara would probably be the one to would go for.

Nolvadex (Tamoxifen Citrate)

Nolvadex is the trade name for the drug tamoxifen citrate, it is an estrogen agonist/antagonist which competitively binds to estrogen receptors in various target tissues. With the tamoxifen molecule bound to this receptor, estrogen is blocked from exerting any action, and an anti-estrogenic effect is achieved. Nolvadex is called a Selective Estrogen Receptor Modulator (SERM) because it is a compound that acts on the estrogen receptor. It should be noted that when one uses nolvadex, since the drug acts to only block the estrogen, your total body estradiol level will increase as there are less receptors that are in a free state to be bound to. It should also be noted that Nolvadex will block most of the estrogen however some will still bind to the estrogen receptors.

Tamoxifen citrate is an antagonist at estrogen receptor in the breast, and a agonist at the estrogen receptor in the uterus. Antagonist meaning inhibiting the affect of estrogen and agonist meaning to stimulate the effect of estrogen in the various tissues. Many forms of breast cancer are responsive to estrogen, the result of tamoxifen citrate used to treat this condition is a very effective form of treatment, as tamoxifen citrate inhibits the estrogen effect in the breast tissue.

Nolvadex is used by bodybuilders that use anabolic/androgenic steroids that aromatase and convert to estrogen. The excess estrogen can result in unwanted side effects, one which is of main concern is gynecomastia or the development of female breast tissue in men. The first symptoms of this are the appearance of swelling or a small lump under the nipple. If left to progress it can turn into a very unsightly development of tissue, often an irreversible occurrence without surgery. This estrogen can also lead to an increase in the levels of water retained by the body. The result here can be a notable loss of definition, the muscles beginning to look smooth and bloated due to the retention of subcutaneous fluid. Fat storage may also be increased as estrogen levels rise. This hormone is the primary reason woman have a higher body fat percentage, and different fat distribution (hips/thighs) than men. Steroid users sensitive to estrogen side effects should have an anti-estrogen on hand when taking problematic steroids to minimize the impact of side effects. It is also to note that when estrogen and body fat levels are normal, administering Nolvadex (both Men and Woman) can increase the look of hardness and definition in muscles.Tamoxifen citrate shows ability to increase the production of FSH (follicle stimulating hormone) and LH (luteinizing hormone) in the male body. This is accomplished by blocking negative feedback inhibition caused by estrogen at the hypothalamus and pituitary, which fosters the release of the mentioned pituitary hormones. Since a higher level of LH can stimulate the Leydig’s cells in the testes to produce more testosterone, Nolvadex can have a positive impact on one’s serum testosterone level. This “testosterone stimulating” effect is an added benefit when preparing to finish a steroid cycle. Since most anabolic/androgenic steroids will suppress endogenous testosterone production, Nolvadex can help restore a balance of hormone levels.Studies have shown that a dose of 20mg of Nolvadex will raise your testosterone levels by around 150%, therefore the use of Nolvadex on a post cycle therapy can greatly aid recovery.

A typical dosage of tamoxifen citrate is around 10 to 30mg, the amount being taken correspondent to the effect desired. It is best to begin with a low dosage of nolvadex and work up to the amount required, as to avoid taking an unnecessary amount. The time in which Nolvadex is started also relies on individual needs of the user. If an athlete with a known sensitivity to estrogen is starting a strong steroid cycle, Nolvadex should probably be added soon after the cycle has been initiated. If estrogen is probably not going to be a major problem during the cycle (but will likely be after), Nolvadex is administered around the time exogenous steroid levels will drop. It will be continued for some weeks after, until the point when natural testosterone is thought to be at an acceptable level.Nolvadex is also and estrogen agonist in the liver, capable of activating the estrogen receptor mimicking the actions of this sex hormone in this region of the body. As such it can have a markedly positive impact on HDL (good) cholesterol values, as does estrogen. Many similarly use this drug to counter some of the negative consequences of steroid use in regards to cholesterol values and cardiac risk, as steroids often suppress HDL and raise LDL levels considerably.

It has been reported by many however that Nolvadex seems to slightly reduce the gains made during a steroid cycle. It appears that many anabolic/androgenic steroids will exhibit their most powerful anabolic effect when accompanied by a sufficient level of estrogen. This may be one reason why gains made with a strong androgen like testosterone are usually much more pronounced than when using an anabolic that aromatizes to a lower degree.It therefore seems like good advice to be aware of how much Nolvadex is actually needed before committing to it during a cycle.

Accutane (Isotretinoin)

Accutane is the brand name Roche uses to market the drug isotretinoin, a potent oral acne medication. Isotretinoin is chemically related to retinoic acid and retinol (Vitamin A), but don’t let this association confuse you. This is a strong synthetic drug, for removed from the relatively benign vitamin it is related to in base structure. Although its exact mode of action is unknown, isotretinoin works by inhibiting sebaceous gland functioning, which diminishes oil production in the skin and hinders acne development. Accutane is sold in many countries thoughout the world, and is largely regarded as one of the most effective medications over developed for treating severe acne. Bodybuilders are attracted to this agent for this same use, namely treating the ever so common side effect of anabolic/anadrogenic steroids use: acne.

Accutane is indeed a very effective medication for its intended use, displaying an excellent success rate with even some the strongest cases of clinical acne (acne vulgaris). For, example, a study was published that involved the treatment of 160 patients in Kuwait. There are many studies that could be referenced showing its high success rate, so this study is not intended to represent the “best” one (simply one of many). The study consisted of a 2 – 28 week treatment peroid, followed by regular checkup visits during the year after. Of the patents that finished the study (133), 127 of them noticed partial or complete clearance of acne during treatment. This was a success rate of over 95%, formidable for any drug. Nearly 60% of these patients were free of relapse a full year after Accutane therapy had been discontinued. This excellent long-term success rate exemplifies why this drug is so highly regarded, at least when it comes to effectiveness.

It isn’t all good for this drug, however. Accutane is extremely powerful, with many potential side effects. In fact, it can be such a serious drug that some might go so far as to call it controversial. Just ask one of the many Accutane action or victim groups. This drug has made front-page papers on many occasions, linked to birth defects, depression, and a string of patient suicides (among other things). The warnings on this product are numerous and very strong. Especially important is for any woman that potentially might become pregnant not use the drug. Even small exposure has been linked to very serious complications with fetal development. It also displays some hepatotoxicity, and can lead to inflammatory bowel disease, pancreatitis, suppressed HDL cholesterol, elevated triglyceride values, and hearing impairment. It may also be linked to a number of other peculiar side effects including psychosis, heart palpitations, hoarseness intracranial hypertension, and even nasal tip deformities when taken following cosmetic surgery. This is, indeed, one weird drug.

Although some researchers have contested the link to depression and suicide, the FDA approved literature on Accutane has warned of these risks for many years now. There seems to be reason, beyond the incidents and statistics alone, to take this very seriously. It appears that Accutane does definitely affect brain function to some degree. This was demonstrated in a study published in early 2005. Here, scientists began with the premise that in order for Accutane to effect depression and thoughts of suicide, it must affect the brain in some way. They set out to examine changes, if any, the drug would have on the various regions of the brain. Twenty-eight people participated in total, approximately half being treated with isotretinoin and the other half a topical antibiotic. Examinations were conducted before the drug was initiated, and after it had been used for 4 weeks. Using positron emisson tomography, they were able to demonstrate a 21% reduction in brain metabolism in the orbitofrontal cortex with Accutane use (there was a 2% increase with the antibiotic). This is a brain area known to mediate symptoms of depression, which suddenly gives this claim a lot more validity and understanding. More work will need to be done in this area before we know anything conclusive of course.

The typical method of using Accutane involves taking a dosage of .5 to 1mg/kg of bodyweight per day. This would equate to a maximum dosage of 100mg daily for a 220lb person. Very severe adult cases (with scarring perhaps) may require upwards adjustments in dosage later on, reaching as high as 2mg/kg/day. The daily dosage later on, reaching as high as 2mg/kg/day. The daily dose itself is divided into two equal doses, which are to be given at two seperate times of the day. Roche is very clear about this, stating that the safety of once daily dosing has not been established and, therefore, is not recommened. Accutane also should be taken with meals, not on an empty stomach, as food significantly aids in the absorption of this drug (high fat meals have the strongest benefit of bioavailability). One course of therapy is usually sufficient to clear up or at least control a patients condition.

Anadrol 50 (Oxymetholone)

• Androgenic 45
• Anabolic 320
• Standard Methyltestosterone (oral)
• Chemical Names 2-hydroxymethylene-17a-methyl-dehydrotestosterone 4,5-dihydro-2-hydroxymethylene-17-alpha-methyltestosterone 17alpha-methyl-2-hydroxymethylene-17-hydroxy-5alpha-androstan-3-one
• Estrogenic Activity high
• Progestational Activity not significant

Description:

Buy Oxymetholone which is a potent oral anabolic steroid derived from dihydrotestosterone. More specifically, it is a close cousin of methyldihydrotestosterone (mestanolone), differing only by the addition of a 2-hydroxymethylene group. This creates a steroid with considerably different activity than mestanolone, however, such that it is very difficult to draw comparisons between the two. For starters, oxymetholone is a very potent anabolic hormone. Dihydrotestosterone and mestanolone are both very weak in this regard, owing to the fact that these molecules are not very stable in the high enzyme (3-alpha hydroxysteroid dehydrogenase) environment of muscle tissue. Oxymetholone remains highly active here instead, as is reported in standard animal assay tests demonstrating a significantly higher anabolic activity than testosterone or methyltestosterone. Such assays suggest the androgenicity of oxymetholone is also very low (1/4th to 1/7th its anabolic activity), although real world results in humans suggest it is decidedly higher than that. You can buy Oxymetholone of high quality from us.

Oxymetholone is considered by many to be the most powerful steroid commercially available. A steroid novice experimenting with this agent is likely to gain 20 to 30 pounds of massive bulk, and it can often be accomplished within 6 weeks of use. This steroid produces a lot of water retention, so a good portion of this gain is going to be water weight. This is often of little consequence to the user, who may be feeling very big and strong while taking oxymetholone. Although the smooth look that results from water retention is often not attractive, it can aid quite a bit to the level of size and strength gained. The muscle is fuller, will contract better, and is provided a level of protection in the form of extra water held into and around connective tissues. Buy Anadrol 50mg as this will allow for more elasticity, and will hopefully decrease the chance for injury when lifting heavy. It should be noted, however, that a very rapid gain in mass might also place too much stress on your connective tissues. The tearing of pectoral and biceps tissue is commonly associated with heavy lifting while massing up on steroids, and oxymetholone is a common offender amongst those who buy oral steroids. There can be such a thing as gaining too fast.

Structural Characteristics:

Buy Oxymetholone which is a modified form of dihydrotestosterone. It differs by 1) the addition of a methyl group at carbon 17-alpha, which helps protect the hormone during oral administration, and 2) the introduction of a 2-hydroxymethylene group, which inhibits its metabolism by the 3-hsd enzyme and greatly enhances the anabolic and relative biological activity of methyldihydrotestosterone.

Side Effects (Estrogenic):

Oxymetholone is a highly estrogenic steroid. Gynecomastia is often a concern during treatment, and may present itself quite early into a cycle (particularly when higher doses are used). At the same time water retention can become a problem, causing notable loss of muscle definition as both subcutaneous water retention and fat levels build. To avoid strong estrogenic side effects, it may be necessary to buy and use an anti-estrogen such as Nolvadex or Clomid.

It is important to note that oxymetholone does not directly convert to estrogen in the body. This steroid is a derivative of dihydrotestosterone, and as such cannot be aromatized. Anti-aromatase compounds like Arimidex will, likewise, not effect the relative estrogenicity of this steroid. Some have suggested that the high level of estrogen activity in oxymetholone is actually due to the drug acting as a progestin, similar to nandrolone. The side effects of both estrogens and progestins can be very similar, which might have made this explanation a plausible one. There was a medical study examining the progestational activity of oxymetholone, however, and it determined that there was no such activity present. With such findings, it seems most plausible that oxymetholone can activate the estrogen receptor, similar to, but more profoundly than, the estrogenic androgen methandriol.

Side Effects (Androgenic):

Although oxymethenolone is classified as an anabolic steroid, androgenic side effects are still common with this substance. These may include bouts of oily skin, acne, and body/facial hair growth. Higher doses are more likely to cause such side effects. Anabolic/androgenic steroids may also aggravate male pattern hair loss. Women who buy and use this agent are also warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. While Anadrol is classified as an anabolic steroid, it does retain a notable androgenic component.

It is interesting to note that oxymetholone does exhibit some tendency to convert to dihydrotestosterone in the body, although this does not occur via the 5-alpha reductase enzyme. Oxymetholone is already a dihydrotestosterone-based steroid, so no such alteration can take place. Aside from the added c-17 alpha alkylation, oxymetholone differs from DHT only by the addition of a 2-hydroxymethylene group. This grouping can be removed metabolically, reducing oxymetholone to the potent androgen 17alpha-methyl dihydrotestosterone (mestanolone). There is little doubt that this biotransformation contributes at least on some level to the androgenic nature of this steroid. Note that since 5-alpha reductase is not involved, the relative androgenicity of oxymetholone is not affected by the concurrent use of finasteride.

Side Effects (Hepatotoxicity):

Oxymetholone is a c17-alpha alkylated compound. This alteration protects the drug from deactivation by the liver, allowing a very high percentage of the drug entry into the bloodstream following oral adminstration. C17-alpha alkylated anabolic/androgenic steroids can be hepatotoxic. Prolonged or high exposure may result in liver damage. In rare instances life threatening dysfunction may develop. It is advisable to visit a physician periodically during each cycle to monitor liver function and overall health. Intake of c17-alpha alkylated steroids is commonly limited to 6 – 8 weeks, in an effort to avoid escalating liver strain.

Oxymetholone has as saturated A-ring, which slightly reduces its relative hepatotoxicity. Still, this agent, particularly at the doses commonly used, can present substantial hepatotoxicity to the user. Studies administering 50mg or 100mg daily to 31 elderly men for 12 weeks produced significant increases in liver enzymes (transaminases AST and ALT) only in patients taking 100mg. A second study administering 50mg daily to 30 patients for up to and exceeding one year (in some patents) has demonstrated elevations in y-glutamyltransferase (GGT) in 17% of patients, significant increases in bilirubin in 10%, and serum albumin increases in 20%. One patient developed a liver tumor that could have been peliosis hepatitis, a life-threatening adverse event characterized by blood filled cysts in the liver. A small number of other cases of peliosis hepatitis have been linked to oxymetholone, suggesting the potential for hepatotoxicity should still be carefully considered before use.

Side Effects (Cardiovascular):

Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendancy to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependent on the dose, route of administration (oral vs. injectable) type of steroid (aromatizable or non-aromatizable), and level of resistance to hepatic metabolism. Anabolic/androgenic steroids may also adversely effect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction.

Oxymetholone has a strong effect on the hepatic management of cholesterol due to its structural resistance to liver breakdown and route of administration. Studies administering 50mg or 100mg daily to a group of elderly men for 12 weeks have demonstrated insignificant increases in LDL cholesterol, accompanied by very significant (dramatic) suppressions of HDL cholesterol (reduced 19 and 23 points in the 50mg and 100mg groups, respectively). The use of oxymetholone should be undertaken only after careful consideration in people with high cholesterol or familial history of heart disease.

Side Effects (Testosterone Suppression):

All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Without the intervention of testosterone-stimulating substances testosterone levels should return to normal within 1 – 4 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention.

Note that when discontinuing oxymetholone, the crash can be as equally powerful as the on-cycle results. To begin with, the level of water retention will quickly diminish, dropping the user’s body weight dramatically. This should be expected, and not of much concern. What is usually of most concern is restoring endogenous testosterone production with a proper Post Cycle Therapy program. Before going off, some alternately choose to first switch over to a milder injectable like Deca-Durabolin for several weeks. This is in an effort to “harden up the new mass,” and can prove to be an effective practice, at least from a mental standpoint. A drop of weight is likely when making the switch, although the end result is still often viewed as allowing the retention of more (quality) muscle mass. It is sort of stepping down, first off the water retention, and weeks later finally of the hormones. Remember ancillaries through, as testosterone production will not be rebounding during Deca therapy.

Administration (General):

Studies have shown that taking an oral anabolic steroid with food may decrease its bioavailability. This is caused by the fat-soluble nature of steroid hormones, which can allow some of the drug to dissolve with undigested dietary fat, reducing its absorption from the gastrointestinal tract. For maximum utilization, this steroid should be taken on an empty stomach.

Administration (Men):

Early prescribing guidelines recommended a dosage of 2.5mg three times per day to reverse the wasting process and provide solid weight gain. Doses as high as 30mg were employed in some cases. Current prescribing guidelines recommend a dosage of 1 – 5mg per kilogram of bodyweight per day for treating anemia, although do indicate that a dose of 1 – 2mg per kilogram is typically sufficient. At a dose of 5mg per kg of weight, a 175-pound person would take a dose of approximately 400mg per day. The same patient would take approximately 150mg (3 tablets) per day at the common 2mg/kg dosage. Therapy is usually given for a minimum of three to six months. When used for physique- or performance-enhancing purposes, and effective oral daily dosage would fall in the range of 25 – 150mg, taken in cycles lasting no more than 6 – 8 weeks to minimize hepatotoxicity. This level is sufficient for dramatic increases in muscle mass and strength. Higher doses are rarely administered due to the strong estrogenic nature of the drug, as well as the high potential for hepatotoxicity.

Administration (Women):

Prescribing information for oxymetholone in the U.S makes no distinction with the dose for females. Oxymetholone is generally not recommended for women for physique- or performance-enhancing purposes due to its very strong nature and tendency to produce virilizing side effects.

Anavar (Oxandrolone)

• Androgenic 24
• Anabolic 322 – 630
• Standard Methyltestosterone (oral)
• Chemical Names 17b-hydroxy-17a-methyl-2-oxa-5a-androstane-3-one
• Estrogenic Activity none
• Progestational Activity none

Description:

Oxandrolone is an oral anabolic steroid derived from dihydrotestosterone. It was designed to have a very strong separation of anabolic and androgenic effect, and on significant estrogenic or progestational activity. Oxandrolone is noted for being quite mild as far as oral steroids are concerned, well tailored for the promotion of strength and quality muscle tissue gains without significant side effects. Milligram for milligram it displays as much as six times the anabolic activity of testosterone in assays, with significantly less androgenicity. This drug is a favorite of dieting bodybuilders and competitive athletes in speed/anaerobic performance sports, where its tendency for pure tissue gain (without fat or water retention) fits well with the desired goals. You can buy Anavar 10mg at affordable prices for body building.

Structural Characteristics:

Oxandrolone is a modified form of dihydrotestosterone. It differs by: 1) the addition of a methyl group at carbon 17-alpha to protect the hormone during oral administration and 2) the substitution of carbon-2 in the A-ring with an oxygen atom. Oxandrolone is the only commercially available steroid with such a substitution to its basic ring structure, an alteration that considerably increases the anabolic strength of the steroid (partly by making it resistant to metabolism by 3-hydroxysteroid dehydrogenase in skeletal muscle tissue).

Side Effects (Estrogenic):

Oxandrolone is not aromatized by the body, and is not measurably estrogenic. Oxandrolone also offer no related progestational activity. An anti-estrogen is not necessary when using this steroid, as gynecomastia should not be a concern even among sensitive individuals. Since estrogen is the usual culprit with water retention, oxandrolone instead produces a lean, quality look to the physique with no fear or excess subcutaneous fluid retention. This makes it a favorable steroid to use during cutting cycles, when water and fat retention are major concerns. Oxandrolone is also very popular among athletes in strength/speed sports such as sprinting, swimming, and gymnastics. In such disciplines one usually does not want to carry around excess water weight, and may find the raw muscle-growth brought about by oxandrolone to be quite favorable over the lower quality mass gains of aromatizable agents.

Side Effects (Androgenic):

Although classified as an anabolic steroid, androgenic side effects are still possible with this substance. This may include bouts of oily skin, acne, and body/facial hair growth. Anabolic/androgenic steroids may also aggravate male pattern hair loss. Women who buy Oxandrolone are also warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Oxandrolone is a steroid with low androgenic activity relative to its tissue-building actions, making the threshold for strong androgenic side effects comparably higher than with more androgenic agents such as testosterone and methandrostenolone.

The low androgenic activity of oxandrolone is due in part to it being a derivative of dihydrotestosterone. This creates a less androgenic steroid because the agent lacks the capacity to interact with the 5-alpha reductase enzyme and convert to a more potent “di-hydro” form. This is unlike testosterone, which is several times more active in androgen responsive target tissues such as the scalp, skin, and prostate (where 5-alpha reductase is present in high amounts) due its its conversion to DHT. In essence, oxandrolone has a more balanced level of potency between muscle and androgenic target tissues. This is a similar situation as is noted with Primobolan and Winstrol, which are also derived from dihydrotestosterone and not known to be very androgenic substances.

Side Effects (Hepatotoxicity):

Oxandrolone is a c17-alpha alkylated compound. This alteration protects the drug from deactivation by the liver, allowing a very high percentage of the drug entry into the bloodstream following oral adminstration. C17-alpha alkylated anabolic/androgenic steroids can be hepatotoxic. Prolonged or high exposure may result in liver damage. In rare instances life threatening dysfunction may develop. It is advisable to visit a physician periodically during each cycle to monitor liver function and overall health. Intake of c17-alpha alkylated steroids is commonly limited to 6 – 8 weeks, in an effort to avoid escalating liver strain.

Oxandrolone appears to offer less hepatic stress than other c-17 alpha alkylated steroids. The manufacturer identifies oxandrolone as a steroid that is not extensively metabolized by the liver like other 17-alpha alkylated orals, which may be a factor in its reduced hepatotoxicity. This is evidenced by the fact that more than a third of the compound is still intact when excreted in the urine. Another study comparing the effects of oxandrolone to other alkylated agents including methyltestosterone, norethandrolone, fluoxymesterone, and methandriol demonstrated that oxandrolone causes the lowest sulfobromophthalein (BSP; a marker of liver stress) retention of the agents tested. 20mg of oxandrolone produced 72% less BSP retention than an equal dosage of fluoxymesterone, which is a considerable difference being that they are both 17-alpha alkylated.

A more recent study looked at escalating doses (20mg, 40mg, and 80mg) of oxandrolone in 262 HIV+ men. The drug was administered for a period of 12 weeks. The group taking 20mg of oxandrolone per day showed no significant trends of hepatotoxicity in liver enzyme (AST/ALT; aminotransferase and alanine aminotransferase) values. Those men taking 40mg noticed a mean increase of approximately 30 – 50% in liver enzyme values, while the group of men taking 80mg noticed an approximate 50 – 100% increase. Approximately 10 – 11% of the patients in the 40mg group noticed World Health Organization grade III and IV toxicity according to AST and ALT values. This figure jumped to 15% in the 80mg group. While serious hepatotoxicity cannot be excluded with oxandrolone, these studies do suggest that it is measurably safer than other alkylated agents.

Side Effects (Cardiovascular):

Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendancy to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependent on the dose, route of administration (oral vs. injectable) type of steroid (aromatizable or non-aromatizable), and level of resistance to hepatic metabolism. Oxandrolone has a strong effect on the hepatic management of cholesterol due to its structural resistance to liver breakdown, non-aromatizable nature, and route of administration. In the previously cited study in HIV+ males, 20mg of oxandrolone daily for 12 weeks caused a mean serum HDL reduction of 30%. HDL values were suppressed 33% in the 40mg group, and 50% in the 80mg group. This was accompanied by a statistically significant increase in LDL values (approximately 30 – 33%) in the 40mg and 80mg groups, further increasing atherogenic risk. Anabolic/androgenic steroids may also adversely effect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction.

At one time oxandrolone was looked at as a possible drug for those suffering from disorders of high cholesterol or triglycerides. Early studies showed it to be capable of lowering total cholesterol and triglyceride values in certain types of hyperlipidemic patients, which was thought to signify potential for this drug as a lipid-lowering agent. With further investigation however, that any lowering of total cholesterol values was accompanied by a redistribution in the ratio of good (HDL) to bad (LDL) cholesterol that favored greater atherogenic risk. This negates any positive effect this drug might have on triglycerides or total cholesterol, and actually makes it a potential danger in terms of cardiac risk, especially when taken for prolonged periods of time. Today we understand that as a group, anabolic/androgenic steroids tend to produce unfavorable changes in blood lipid profiles, and are really not useful in disorders of lipid metabolism. As an oral c17 alpha alkylated steroid, oxandrolone is even more risky to use in this regard than an esterfied injectable such as a testosterone or nandrolone.

Side Effects (Testosterone Suppression):

All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Oxandrolone is no exception. In the above-cited study on HIV+ males, twelve weeks of 20mg or 40mg per day caused an approximate 45% reduction in serum testosterone levels. The group taking 80mg noticed a 66% decrease in testosterone. Similar trends of decrease were noticed in LH production, with 20mg and 40mg doses causing a 25 – 30% reduction, and the 80mg group noticing a decline of more than 50%. Additionally, studies on boys with constitutionally delayed puberty have demonstrated significant suppression of endogenous LH and testosterone with as little as 2.5mg per day. Without the intervention of testosterone-stimulating substancestestosterone levels should return to normal within 1 – 4 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention.

Administration (General):

Studies have shown that taking an oral anabolic steroid with food may decrease its bioavailability. This is caused by the fat-soluble nature of steroid hormones, which can allow some of the drug to dissolve with undigested dietary fat, reducing its absorption from the gastrointestinal tract. For maximum utilization, this steroid should be taken on an empty stomach.

Administration (Men):

The original prescribing guidelines for Anavar called for a daily dosage of between 2.5mg and 20mg per day (5 – 10mg being most common). This was usually recommended for a period of two to four weeks, but occasionally it was taken for as long as three months. The dosing guidelines recommended with the current U.S. production of the drug (Oxandrin, Savient Pharmaceuticals) also call for between 2.5 and 20mg of drug per day, taken in intermittent cycles of 2 to 4 weeks. The usual dosage for men who buy and use it for physique- or performance-enhancing purposes is in the range of 15 – 25mg per day, taken for 6 to 8 weeks. These protocols are not far removed from those of normal theapeutic situations.

Oxandrolone is often combined with other steroids for a more dramatic result. For example, while bulking one might opt to add in 200 – 400mg of a testosterone ester (cypionate, enanthate, or propionate) per week. The result should be a considerable gain in new muscle mass, with a more comfortable level of water and fat retention than if taking a higher dose of testosterone alone. For dieting phases, one might alternatively combine oxandrolone with a non-aromatizing steroid such as 150mg per week of a trenbolone ester or 200 – 300mg of Primobolan (methenolone enanthate). Such stacks are highly favored for increasing definition and muscularity. An in-between (lean mass gain) might be to add in 200 – 400mg of a low estrogenic compound like Deca-Durabolin (nandrolone decanoate) or Equipose (boldenone undecylenate).

Administration (Women):

The original prescribing guidelines for Anavar did not offer separate dosing recommendations for women, although it was indicated that women who were pregnant, or may become pregnant, should not use the drug. The current guidelines for Oxandrin also do not make special dosing recommendations for women. Women who fear the masculinizing effects of many steroids would be quite comfortable using this drug, as these properties are very rarely seen with low doses. For women who buy and use it physique- or performance-enhancing purposes, a daily dosage or 5 – 10mg should illicit considerable growth without the noticeable androgenic side effects of other drugs. This would be taken for no longer than 4 – 6 weeks. Eager females may wish to add another mild anabolic such as Winstrol, Primobolan, or Durabolin. When combined with such anabolics, the user should notice faster, more pronounced muscle-building effects, but it may also increase the likelihood of seeing androgenic side effects (or hepatotoxicity in the case of Winstrol).

Andriol (Testosterone Undecanoate)

• Androgenic 100
• Anabolic 100
• Standard Standard
• Chemical Names 4-androsten-3-one-17beta-ol17beta-hydroxy-androst-4-en-3-one
• Estrogenic Activity moderate
• Progestational Activity low

Description:

Andriol is an oral testosterone preparation that contains 40mg of testosterone undecanoate (in an oil base) in a soft gelatin capsule. This drug is very different than most oral anabolic steroids, which are c-17 alpha alkylated to survive first pass metabolism through the liver. Instead, esterification and suspension in oil allows the testosterone undecanoate in Andriol to be partially absorbed through the lymphatic system along with dietary fat. This bypasses the destructive first-pass through liver, providing sustained physiological levels of testosterone to the body. The actual oral bioavailability of Andriol is estimated to be approximately 7%. In design, this steroid is essentially a non-toxic and orally active testosterone, intended to provide a unique alternative to testosterone injections and other hepatotoxic oral anabolic/androgenic steroids.

Structural Characteristics:

Andriol contains testosterone that has been modified with the addition of carboxylic acid ester (undecanoic acid) at the 17-beta hydroxyl group. The esterified hormone is more fat soluble than base (free) testosterone, and had been dissolved in oil and encapsulated for oral administration. Significant absorption of oral testosterone undecanoate takes place through the lymphatic route, bypassing the first pass through the liver. Andriol is designed to provide a peak in testosterone levels several hours after administration, and with repeated dosing maintain physiological concentrations for 24 hours.

Side Effects (Estrogenic):

Testosterone is readily aromatized in the body to estradiol (estrogen). The aromatase (estrogen synthetase) enzyme is responsible for this metabolism of testosterone. Elevated estrogen levels can cause side effects such as increased water retention, body fat gain, and gynecomastia. Testosterone is considered moderately estrogenic steroid. An anti-estrogen such as clomiphene citrate or tamoxifen citrate may be necessary to prevent estrogenic side effects. One may alternatively use an aromatase inhibitor like Arimidex (anastrozole), which more efficiently controls estrogen by preventing its synthesis. Aromatase inhibitors can be quite expensive in comparison to anti-estrogens, however, and may also have negative effects on blood lipids.

Side Effects (Androgenic):

Testosterone is the primary male androgen, responsible for maintaining secondary male sexual characteristics. Elevated levels of testosterone are likely to produce androgenic side effects including oily skin, acne, and body/facial hair growth. Men with a genetic predisposition for hair loss (androgenic alopecia) may notice accelerated male pattern balding. Those concerned about hair loss may find a more comfortable option in nandrolone decanoate, which is a comparably less androgenic steroid. Women are warned of the potential virilizing effect of anabolic/androgenic steroids, especially with a strong androgen such as testosterone. These may include deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement.

In androgen-responsive target tissues such as the skin, scalp, and prostate, the high relative androgenicity of testosterone is dependent on its reduction to dihydrostestosterone (DHT). The 5-alpha reductase enzyme is responsible for this metabolism of testosterone. The concurrent use of a 5-alpha reductase inhibitor such as finasteride will interfere with site-specific potentation of testosterone action, lowering the tendency of testosterone drugs to produce androgenic side effects. It is important to remember that anabolic and androgenic effects are both mediated via the cytosolic androgen receptor. Complete separation of testosterone’s anabolic and androgenic properties is not possible, even with total 5-alpha reductase inhibition.

Side Effects (Hepatotoxicity):

Testosterone does not have hepatotoxic effects; liver toxicity is unlikely. One study examined the potential for hepatotoxicity with high doses of testosterone by administering 400mg of the hormone per day (2,800mg per week) to a group of male subjects. The steroid was taken orally so that higher peak concentrations would be reached in hepatic tissues compared to intramuscular injections. The hormone was given daily for 20 days, and produced no significant changes in liver enzyme values including serum albumin, bilirubin, alanine-amino-transferase, and alkaline phosphatases.

Side Effects (Cardiovascular):

Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendancy to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependent on the dose, route of administration (oral vs. injectable) type of steroid (aromatizable or non-aromatizable), and level of resistance to hepatic metabolism. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction. Therapeutic doses of oral testosterone undecanoate used to correct insufficient androgen production in otherwise healthy aging men are unlikely to increase atherogenic risk, and may actually improve lipid profiles and cardiovascular risk factors.

Side Effects (Testosterone Suppression):

All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Testosterone is the primary male androgen, and offers strong negative feedback on endogenous testosterone production. Testosterone-based drugs will, likewise, have a strong effect on the hypthalamic regulation of natural steroid hormones. Without the intervention of testosterone-stimulating substances, testosterone levels should return to normal within 1 – 4 months of drug secession. Not that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention.

Administration (General):

Andriol should always be taken with meals, preferably containing a moderate fat content (20 grams) to maximize lymphatic absorbption. Very low bioavailability has been reported when taken in the fasted state. The total daily dosage should be divided into a minimum of two applications, taken in the morning and evening, to maintain more consistent elevations of serum testosterone.

Administration (Men):

For treatment of low androgen levels, prescribing guidelines for Andriol recommend an initial dosage of 120 – 160mg daily for 2 – 3 weeks. Based on the level of effect, a daily maintenance dosage of 40 – 120mg is usually continued at this point. For bodybuilding purposes, higher doses would be required to reach strong supraphysiological levels of testosterone. This would generally call for a minimum dosage of 240 – 280mg per day (6 – 8 capsules) per day. These doses can be quite costly given the relative price of Andriol preparations, making injectable testosterones much more cost effective and popular. Given the relative potency of Andriol, when taken by athletes it is most commonly use in combination with other agents. Testosterone drugs are ultimately versatile, and can be stacked with many other anabolic/androgenic steroids depending on the desired effect.

Administration (Woman):

Andriol is not prescribed to woman in clinical medicine. This drug is not recommended for women for physique- or performance-enhancing purposes due to its strong androgenic nature and tendency to produce virilizing side effects.

Deca-Durabolin (Nandrolone Decanoate)

• Androgenic 37
• Anabolic 125
• Standard Testosterone
• Chemical Names 19-norandrost-4-en-3-one-17beta-ol 17beta-hydroxy-estr-4-en-3-one
• Estrogenic Activity low
• Progestational Activity moderate

Description:

Nandrolone decanoate is an injectable form of the anabolic steroid nandrolone. The decanoate ester provides a slow release of nandrolone from the site of injection, lasting for up to three weeks. Nandrolone is very similar to testosterone in structure, although it lacks a carbon atom at the 19th position (hence its other name, 19-nortestosterone). Like tesosterone, nandrolone exhibits relatively strong anabolic properties. Unlike testosterone however, its tissue-building activity are accompanied by weak androgenic properties. Much of this has to do with the reduction of nandrolone to a weaker steroid, dihydrotestosterone, in the same androgen-responsive target tissues that potentate the action of testosterone (by converting it to DHT). The mild properties of nandrolone decanoate have made it one of the most popular injectable steroids worldwide, highly favored by athletes for its ability to promote significant strength and lean mass gains without strong androgenic or estrogenic side effects. Buy Deca Durabolin 100 Injection from us at reasonable prices.

Structural Characteristics:

Nandrolone decanoate is a modified form of nandrolone, where a carboxylic acid ester (decanoic acid) has been attached to the 17-beta hydroxyl group. Buy Deca Durabolin 100 categorized as Esterified steroids that are less polar than free steroids, and are absorbed more slowly from the area of injection. Once in the bloodstream, the ester is removed to yield free (active) nandrolone. Esterified steroids are designed to prolong the window of therapeutic effect following administration, allowing for a less frequent injection schedule compared to injections of free (unesterified) steroid. Nandrolone decanoate provides a sharp spike in nandrolone release 24 – 48 hours following deep intramuscular injection, which steadily declines to near baseline levels approximately two weeks later. The mean depot-release half-life of nandrolone decanoate is 8 days.

Side Effects (Estrogenic):

Nandrolone has a low tendency for estrogen conversion, estimated to be only about 20% of that seen with testosterone. This is because while the liver can convert nandrolone to estradiol, in other more active sites of steroid aromatization such as adipose tissue nandrolone is far less open to this process. Consequently, estrogen-related side effects are a much lower concern with this drug than testosterone. Elevated estrogen levels may still be noticed with higher dosing, however, and may cause side effects such as increased water retention, body fat gain, and gynecomastia. An anti-estrogen such as clomiphene citrate or tamoxifen citrate may be necessary to prevent estrogenic side effects if they occur. One may alternately use an aromatase inhibitor like Arimidex (anastrozole), which more efficiently controls estrogen by preventing its synthesis. Aromatase inhibitors can be quite expensive in comparison to anti-estrogens, however, and may also have negative effects on blood lipids.

It is of note that nandrolone has some activity as a progestin in the body. Although progesterone is a c-19 steroids, removal of this group as in 19-norprogesterone creates a hormone with greater binding affinity for its corresponding receptor. Sharing this trait, many 19-nor anabolic steroids are shown to have some affinity for the progesterone receptor as well. The side effects associated with progesterone are similar to those of estrogen, including negative feedback inhibition of testosterone production and enhanced rate of fat storage. Progestins also augment the stimulatory effect of estrogens on mammary tissue growth. There appears to be a very strong synergy between these two hormones here, such that gynecomastia might even occur with the help of progestins, without excessive estrogen levels. The use of an anti-estrogen, which inhibits the estrogenic component of this disorder, is often sufficient to mitigate gynecomastia caused by nandrolone.

Side Effects (Androgenic):

Although classified as an anabolic steroid, androgenic side effects are still possible with this substance, especially with higher doses. This may include bouts of oily skin, acne, and body/facial hair growth. Anabolic/androgenic steroids may also aggravate male pattern hair loss. Women are also warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Nandrolone is a steroid with relatively low androgenic activity relative to its tissue-building actions, making the threshold for strong androgenic side effects comparably higher than with more androgenic agents such as testosterone or methandrostenolone. It is also important to point out that due to its mild androgenic nature and ability to suppress endogenous testosterone, nandrolone is prone to interfering with libido in males when used without another androgen.

Note that in androgen-responsive target tissues such as the skin scalp, and prostate, the relative androgenicity of nandrolone is reduced by its reduction to dihydronandrolone (DHN). The 5-alpha reductase enyzme is responsible for this metabolism of nandrolone. The concurrent use of a 5-alpha reductase inhibitor such as finasteride will interfere with site-specific reduction of nandrolone action, considerably increasing the tendency of nandrolone to produce androgenic side effects. Reductase inhibitors should be avoided with nandrolone if low androgenicity is desired.

Side Effects (Hepatotoxicity):

Buy Nandrolone which is not c-17 alpha alkylated, and not known to have hapatotoxic effects in healthy subjects. Liver toxicity is unlikely.

Side Effects (Cardiovascular):

Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendancy to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependent on the dose, route of administration (oral vs. injectable) type of steroid (aromatizable or non-aromatizable), and level of resistance to hepatic metabolism. Studies administering 600mg of nandrolone decanoate per week for 10 weeks demonstrated a 26% reduction in HDL cholesterol levels. This suppression is slightly greater than that reported with an equal dose of testosterone enanthate, and is in agreement with earlier studies showing a slightly stronger negative impact on HDL/LDL ratio with nandrolone decanoate as compared to testosterone cypionate. Nandrolone decanoate should still have a significantly weaker impact on serum lipids than c-17 alpha alkylated agents. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction.

Side Effects (Testosterone Suppression):

All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Studies administering 100mg per week of nandrolone decanoate for 6 weeks have demonstrated an approximate 57% reduction in serum testosterone levels during therapy. At a dosage of 300mg per week, this reduction reached 70%. It is believed that the progestational activity of nandrolone notably contributes to the suppression of testosterone synthesis during therapy, which can be marked in spite of low tendency for estrogen conversion. Without the intervention of testosterone-stimulating substances, testosterone levels should return to normal within 2 – 6 months of drug succession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention.

Administration (Men):

For general anabolic effects, early prescribing guidelines recommend a dosage of 50 – 100mg every 3 – 4 weeks for 12 weeks. To treat renal anemia, the prescribing guidelines for nandrolone decanoate recommend a dosage of 100 – 200mg per week. The usual dosage for physique- or performance-enhancing purposes is the range of 200 – 600mg per week, taken in cycles 8 to 12 weeks in length. This is sufficient for most users to notice measurable gains in lean muscle mass and strength. It is often stated that nandrolone decanoate will exhibit its optimal effect (best gain/side effect ration) at 2mg per pound of bodyweight/weekly, although individual differences in response will likely dictate varying ideal doses for different users. Deca is not known as a very “fast” builder. The muscle-building effect of this drug is quite noticeable, but not dramatic. In general, one can expect to gain muscle weight at about half the rate of that with an equal amount of testosterone.

Nandrolone decanoate is often combined with other steroids for an enhanced effect. A combination of 200 – 400mg/ week of nandrolone decanoate and 10 – 20mg of Winstrol, for example, is noted to greatly enhance the look of muscularity and definition when dieting/cutting. A strong non-aromatizing androgen like trenbolone could also be used, again providing and enhanced level of hardness and density to the muscles. Being a moderately strong muscle builder, nandrolone can also be incorporated into bulk cycles with acceptable results. Buy the classic “Deca and D-bol” stack (usually 200 – 400mg of nandrolone per week and 15 – 25 mg of Dianabol per day) that has been a bodybuilding basic for decades, and always seems to provide excellent muscle growth. A stronger androgen such as Anadrol 50 or testosterone could also be substituted, producing greater results, but with more water retention.

Administration (Woman):

For general anabolic effects, early prescribing guidelines recommend a dosage of 50 – 100mg every 3 – 4 weeks for 12 weeks. To treat renal anemia, the prescribing guidelines for nandrolone decanoate recommend a dosage of 50 – 100mg per week. When used for physique- or performance-enhancing purposes, a dosage of 50mg per week is most common, taken for 4 – 6 weeks. Although only slightly androgenic, women are occasionally confronted with virilization when taking this compound. Studies have demonstrated high tolerability (minor but statistically insignificant incidence of virilizing side effects) with a dose of 100mg every other week for 12 weeks, while long-term studies (+12 months of use) have demonstrated virilizing side effects of a dose as low as 50mg every 2 – 3 weeks. Should virilizing side effects become a concern nandrolone decanoate should be discontinued immediately to help prevent their permanent appearance. After a sufficient period of withdrawal, the shorter-acting nandrolone Durabolin might be considered a safer option. This drug stays active for only several days, greatly reducing the withdrawal time if indicated.